In the Madhyamakalankara, Shantarakshita synthesized the views of Madhyamaka and Yogachara, the two great streams of Mahayana Buddhism. This was the last great philosophical development of Buddhist India.

In his brilliant and searching commentary, Mipham re-presented Shantarakshita to a world that had largely forgotten him, defending his position and showing how it should be understood in relation to the teaching of Chandrakirti. To do this, he subtly reassessed the Svatantrika-Prasangika distinction, thereby clarifying and rehabilitating Yogachara-Madhyamaka as a bridge whereby the highest philosophical view on the sutra level flows naturally into the view of tantra. Mipham's commentary has with reason been described as one of the most profound examinations of Madhyamaka ever written.