This publication outlines how the One Health approach can be stepped up in the Greater Mekong Subregion to address climate change, boost food security, and tackle disease resistance to help optimize the health of people, animals, and ecosystems.

The publication addresses the use of wildlife, underlines the need to ramp up action against diseases such as rabies, and shows why countries should build up their animal health capacities. Drawing on the lessons learned from the pandemic, it identifies investment opportunities and recommends countries improve regional cooperation, reinforce infrastructure, and build on One Health coordination mechanisms to protect regional health security.