Science as a Spiritual Practice is in three parts. In the first part the author argues that there are problems with materialism and that self-transformation could lead individual scientists to more comprehensive ways of understanding reality. In the second part he takes on the contentious notion of inner knowledge and shows how access to inner knowledge could be possible in some altered states of consciousness. The third part is an analysis of the philosophy of Franklin Wolff, who claimed that the transcendent states of consciousness which occurred for him resulted from his mathematical approach to spirituality.