Book 2 is divided into two. The first half completes the remaining topics Louis taught in his The Clinical Biology and Aches and Pains course. Topics include the brain, the Mature organism Model and the brain. Stress and chronic stress are discussed and related to the patient in front of the clinician.

The Nerve Root course was first taught in 2000. Topics covered are peripheral nerve mechanisms, nerve and nerve root pain. 'Discs' are given a whole section and findings are again interpreted with the patient foremost.