The riveting account of a community from the remote mountains of Colombia whose rare and fatal genetic mutation is unlocking the secrets of Alzheimer's disease

Powerful. . . . a poignant depiction of a community in crisis. --Publishers Weekly

In the 1980s, a neurologist named Francisco Lopera traveled on horseback into the mountains seeking families with symptoms of dementia. For centuries, residents of certain villages near Medellín had suffered memory loss as they reached middle age, going on to die in their fifties. Lopera discovered that a unique genetic mutation was causing their rare hereditary form of early onset Alzheimer's disease. Over the next forty years of working with the paisa mutation kindred, he went on to build a world-class research program in a region beset by violence and poverty.

In Valley of Forgetting, Jennie Erin Smith brings readers into the clinic, the laboratories, and the Medellín trial center where Lopera's patients receive an experimental drug to see if Alzheimer's can be averted. She chronicles the lives of people who care for sick parents, spouses, and siblings, all while struggling to keep their own dreams afloat. These Colombian families have donated hundreds of their loved ones' brains to science and subjected themselves to invasive testing to help uncover how Alzheimer's develops and whether it can be stopped. Findings from this unprecedented effort could hold the key to understanding and treating the disease, though it is unclear what, if anything, the families will receive in return.

Smith's immersive storytelling brings this complex drama to life, inviting readers on a scientific journey that is as deeply moving as it is engrossing.

The million copy international bestseller, critically acclaimed and translated into over 25 languages.

As influential today as when it was first published, The Selfish Gene has become a classic exposition of evolutionary thought. Professor Dawkins articulates a gene's eye view of evolution - a view giving centre stage to these persistent units of information, and in which organisms can be seen as vehicles for their replication. This imaginative, powerful, and stylistically brilliant work not only brought the insights of Neo-Darwinism to a wide audience, but galvanized the biology community, generating much debate and stimulating whole new areas of research. Forty years later, its insights remain as relevant today as on the day it was published.

This 40th anniversary edition includes a new epilogue from the author discussing the continuing relevance of these ideas in evolutionary biology today, as well as the original prefaces and foreword, and extracts from early reviews.

Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think.

For more than 150 years, the question of nature versus nurture has been one of the most contentious issues in the human sciences. On the one side are blank-slaters, who believe we are mainly shaped by our environment. On the other side are hereditarians, who believe in the primacy of genes. From the start, the fight has been highly politicized and extremely bitter, given that it has implications for how we think about racial disparities, meritocracy, reproduction, and free will itself. In The Social Genome, pioneering scientist Dalton Conley demonstrates that this longstanding debate is fundamentally misguided. The true question is not nature versus nurture, but how nature and nurture interact to make each of us who we become.

The Social Genome is a sweeping account of the sociogenomics revolution, which has, in the last decade, upended many of our notions about human development. Sociogenomics brings together advances in molecular genetics and traditional social and behavioral science. The key tool is the polygenic index, which allows us to analyze DNA to measure a child's genetic potential. Today, we can estimate a child's adult height, how far they will go in school, and their weight as an adult--all from a cheek swab, finger prick, or vial of saliva. Conley and other researchers are using this new science to shed light on the ways in which genes shape our world, influencing how each person both creates and responds to the environment around them. Conley reveals a world where children's DNA influences the nurture they extract from their parents; the genes of our schoolmates affect our likelihood of smoking as much as our own DNA does; and spouses' genes influence each other's moods and behaviors. Looking forward, Conley envisions a future where dating, education, public health, and other institutions have been radically altered by the sociogenomic revolution.

As Conley argues, we should no longer think of nature versus nurture, but about how our genes seek the nurture they need to express themselves and how, in turn, our environments are made partly from the genes of other people. The Social Genome presents a nuanced, powerful perspective on individual potential and social dynamics and raises critical ethical questions about how we will navigate a future where we have access to far more genetic information than ever before.

A Copernican revolution for the life sciences.--Medical Tribune

Unlock the mysteries of biology, anthropology, and ancient civilizations in this thought-provoking read where science and spirituality intersect.

Through Jeremy Narby′s travels and research in the Amazon, he discovered that shamans were able to use hallucinogens to tap into knowledge and insights that rival our discoveries using modern scientific methods, particularly with regards to DNA and molecular biology. Drawing on visionary experiences, indigenous knowledge, and pharmacology, Narby challenges conventional understanding, unraveling the connections between consciousness, serpent symbolism, and the origins of life itself. This enlightening book blends science, anthropology, and mysticism into a captivating narrative that will expand your mind.

The classic personal account of Watson and Crick's groundbreaking discovery of the structure of DNA, now with an introduction by Sylvia Nasar, author of A Beautiful Mind.

By identifying the structure of DNA, the molecule of life, Francis Crick and James Watson revolutionized biochemistry and won themselves a Nobel Prize. At the time, Watson was only twenty-four, a young scientist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science's greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions, and bitter rivalries.

With humility unspoiled by false modesty, Watson relates his and Crick's desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work.

Signature in the Cell is a defining work in the discussion of life's origins and the question of whether life is a product of unthinking matter or of an intelligent mind. For those who disagree with ID, the powerful case Meyer presents cannot be ignored in any honest debate. For those who may be sympathetic to ID, on the fence, or merely curious, this book is an engaging, eye-opening, and often eye-popping read -- American Spectator

Named one of the top books of 2009 by the Times Literary Supplement (London), this controversial and compelling book from Dr. Stephen C. Meyer presents a convincing new case for intelligent design (ID), based on revolutionary discoveries in science and DNA. Along the way, Meyer argues that Charles Darwin's theory of evolution as expounded in The Origin of Species did not, in fact, refute ID. If you enjoyed Francis Collins's The Language of God, you'll find much to ponder--about evolution, DNA, and intelligent design--in Signature in the Cell.

Genetic Entropy presents compelling scientific evidence that the genomes of all living creatures are slowly degenerating - due to the accumulation of slightly harmful mutations. This is happening in spite of natural selection. The author of this book, Dr. John Sanford, is a Cornell University geneticist. Dr. Sanford has devoted more than 10 years of his life to the study of this specific problem. Arguably, he has examined this problem in greater depth than any other scientist. The evidences that he presents are diverse and compelling. He begins by examining how random mutation and natural selection actually operate, and shows that simple logic demands that genomes must degenerate. He then makes a historical examination of the relevant field (population genetics), and shows that the best scientists in that field have consistently acknowledged many of the fundamental problems he has uncovered (but they have failed to communicate these problems to the broader scientific community). He then shows, in collaboration with a team of other scientists, that state-of-the-art numerical simulation experiments consistently confirm the problem of genetic degeneration (even given very strong selection and optimal conditions). Lastly, in collaboration with other scientists, he shows that real biological populations clearly manifest genetic degeneration. Dr. Sanford's findings have enormous implications. His work largely invalidates classic neo-Darwinian theory. The mutation/selection process by itself is not capable of creating the new biological information that is required for creating new life forms. Dr. Sanford shows that not only is mutation/selection incapable of creating our genomes - it can't even preserve our genomes. As biochemist Dr. Michael Behe of Lehigh University writes in his review of Genetic Entropy, ...not only does Darwinism not have answers for how information got into the genome, it doesn't even have answers for how it could remain there. Dr. Sanford has coined the term genetic entropy to describe this fatal flaw of neo-Darwinian theory. This fundamental problem has been something of a trade-secret within the field of population genetics, with the rest of the world largely being kept in the dark. Fortunately, this book finally discloses this very serious problem, using language that is for the most part accessible to all scholars and students having a basic understanding of biology. This new edition of Genetic Entropy includes numerous new lines of evidence supporting Dr. Sanford's thesis. Much of this new evidence is from recently published scientific papers that are now part of the scientific literature. Genetic Entropy is a must-read for any thoughtful person who in interested in science. Dr. Sanford ends his book by asking two questions. First, if our genome did not actually arise via the accumulation of genetic word-processing errors (as is claimed), how did it arise? Second, if our genomes are undergoing relentless degeneration - where can we possibly place our hope for the future?

Ridley leaps from chromosome to chromosome in a handy summation of our ever increasing understanding of the roles that genes play in disease, behavior, sexual differences, and even intelligence. . . . . He addresses not only the ethical quandaries faced by contemporary scientists but the reductionist danger in equating inheritability with inevitability. -- The New Yorker

The genome's been mapped. But what does it mean? Matt Ridley's Genome is the book that explains it all: what it is, how it works, and what it portends for the future

Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life.

Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.

Over the past thirty years, a new systemic conception of life has emerged at the forefront of science. New emphasis has been given to complexity, networks, and patterns of organisation, leading to a novel kind of 'systemic' thinking. This volume integrates the ideas, models, and theories underlying the systems view of life into a single coherent framework. Taking a broad sweep through history and across scientific disciplines, the authors examine the appearance of key concepts such as autopoiesis, dissipative structures, social networks, and a systemic understanding of evolution. The implications of the systems view of life for health care, management, and our global ecological and economic crises are also discussed. Written primarily for undergraduates, it is also essential reading for graduate students and researchers interested in understanding the new systemic conception of life and its implications for a broad range of professions - from economics and politics to medicine, psychology and law.

Evolve your knowledge of the fast-moving world of genetic research

Genetics For Dummies shines a light on the fascinating field of genetics, helping you gain a greater understanding of how genetics factors into everyday life. Perfect as a supplement to a genetics course or as an intro for the curious, this book is packed with easy-to-understand explanations of the key concepts, including an overview of cell biology. You'll also find tons of coverage of recent discoveries in the field, plus info on how genetics can affect your health and wellbeing. Whole-genome sequencing, genetic disease treatments, exploring your ancestry, non-invasive prenatal testing--it's all here, in the friendly and relatable Dummies style you love.

• Grasp the basics of cell biology and get a primer on the field of genetic research
• Discover what you can learn about yourself, thanks to advances in genetic testing
• Learn how your genes influence your health and wellbeing, today and as you age
• Follow along with your college-level genetics course--or refresh your knowledge--with clear explanations of complex ideas

Genetics For Dummies is great for students of the biological sciences, and for the genetically curious everywhere.

BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY Finalist for the Los Angeles Times Book Prize

A powerful mix of science and ethics . . . This book is required reading for every concerned citizen--the material it covers should be discussed in schools, colleges, and universities throughout the country.-- New York Review of Books

Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR--a revolutionary new technology that she helped create--to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create better humans. Writing with fellow researcher Sam Sternberg, Doudna--who has since won the Nobel Prize for her CRISPR research--shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life.

The future is in our hands as never before, and this book explains the stakes like no other. -- George Lucas

An invaluable account . . . We owe Doudna several times over. -- Guardian

In our unique genomes, every one of us carries the story of our species--births, deaths, disease, war, famine, migration, and a lot of sex. But those stories have always been locked away--until now. Who are our ancestors? Where did they come from? Geneticists have suddenly become historians, and the hard evidence in our DNA has blown the lid off what we thought we knew. Acclaimed science writer Adam Rutherford explains exactly how genomics is completely rewriting the human story--from 100,000 years ago to the present.

From New York Times bestselling author Sam Kean comes incredible stories of science, history, language, and music, as told by our own DNA.

In The Disappearing Spoon, bestselling author Sam Kean unlocked the mysteries of the periodic table. In The Violinist's Thumb, he explores the wonders of the magical building block of life: DNA.

There are genes to explain crazy cat ladies, why other people have no fingerprints, and why some people survive nuclear bombs. Genes illuminate everything from JFK's bronze skin (it wasn't a tan) to Einstein's genius. They prove that Neanderthals and humans bred thousands of years more recently than any of us would feel comfortable thinking. They can even allow some people, because of the exceptional flexibility of their thumbs and fingers, to become truly singular violinists.

Kean's vibrant storytelling once again makes science entertaining, explaining human history and whimsy while showing how DNA will influence our species' future.

Have you ever heard of a person who left you wondering, How could someone be so twisted? So evil? Prompted by clues in her sister's diary after her mysterious death, author Barbara Oakley takes the reader inside the head of the kinds of malevolent people you know, perhaps all too well, but could never understand.Starting with psychology as a frame of reference, Oakley uses cutting-edge images of the working brain to provide startling support for the idea that evil people act the way they do mainly as the result of a dysfunction. In fact, some deceitful, manipulative, and even sadistic behavior appears to be programmed genetically-suggesting that some people really are born to be bad.Oakley links the latest findings of molecular research to a wide array of seemingly unrelated historical and current phenomena, from the harems of the Ottomans and the chummy jokes of Uncle Joe Stalin, to the remarkable memory of investor Warren Buffet. Throughout, she never loses sight of the personal cost of evil genes as she unravels the mystery surrounding her sister's enigmatic life-and death.Evil Genesis a tour-de-force of popular science writing that brilliantly melds scientific research with intriguing family history and puts both a human and scientific face to evil.

Beyond DNA is a journey through uncharted territory, advancing new ways of thinking about evolution and adaptation. For nearly a hundred years evolutionary biologists have understood that evolution proceeds by substituting better genes for less good ones. But consensus is growing that this is not the whole story: geneticists are now revealing that spores, sperm, pollen and ova are packed with personalised genetic information that plays an important role in offspring development and has lifelong effects. This epigenetic - or 'extra-genetic '-inheritance therefore makes significant contributions to evolutionary processes. In this highly accessible book, packed with instructive examples, Benjamin Oldroyd explains how a greater appreciation of the role of epigenetics is helping to solve a multitude of previously intractable problems in evolutionary biology - puzzles as varied as why invasive plants and animals can rapidly adapt to changes in their environment, how worker bees and queen bees can develop from the same egg, and why cancer becomes more common as we age.

Have you ever asked yourself:

Are spliced genes the same as mended Levis?

Watson and Crick? Aren't they a team of British detectives?

Plant sex? Can they do that?

Is Genetic Mutation the name of one of those heavy metal bands?

Asparagine? Which of the four food groups is that in?

Then you need The Cartoon Guide to Genetics to explain the important concepts of classical and modern genetics--it's not only educational, it's funny too

The Lucifer Principle is a revolutionary work that explores the intricate relationships among genetics, human behavior, and culture to put forth the thesis that evil is a by-product of nature's strategies for creation and that it is woven into our most basic biological fabric.

In a sweeping narrative that moves lucidly among sophisticated scientific disciplines and covers the entire span of the earth's, as well as mankind's, history, Howard Bloom challenges some of our most popular scientific assumptions. Drawing on evidence from studies of the most primitive organisms to those on ants, apes, and humankind, the author makes a persuasive case that it is the group, or 'superorganism, rather than the lone individual that really matters in the evolutionary struggle. But, Bloom asserts, the prominence of society and culture does not necessarily mitigate against our most violent, aggressive instincts. In fact, under the right circumstances, the mentality of the group will only amplify our most primitive and deadly urges.

In Bloom's most daring contention he draws an analogy between the biological material whose primordial multiplication began life on earth and the ideas, or 'memes, that define, give cohesion to, and justify human superorganisms. Some of the most familiar memes are utopian in nature Christianity or Marxism; nonetheless, these are fueled by the biological impulse to climb to the top of the hierarchy. With the meme's insatiable hunger to enlarge itself, we have a precise prescription for war.

Biology is not destiny, but human culture is not always the buffer to our most primitive instincts we would like to think it is. In these complex threads of thought lies the Lucifer Principle, and only through understanding its mandates will we able to avoid the nuclear crusades that await us in the twenty-first century.

A groundbreaking book about how ancient DNA has profoundly changed our understanding of human history.

Geneticists like David Reich have made astounding advances in the field of genomics, which is proving to be as important as archeology, linguistics, and written records as a means to understand our ancestry.

In Who We Are and How We Got Here, Reich allows readers to discover how the human genome provides not only all the information a human embryo needs to develop but also the hidden story of our species. Reich delves into how the genomic revolution is transforming our understanding of modern humans and how DNA studies reveal deep inequalities among different populations, between the sexes, and among individuals. Provocatively, Reich's book suggests that there might very well be biological differences among human populations but that these differences are unlikely to conform to common stereotypes.

Drawing upon revolutionary findings and unparalleled scientific studies, Who We Are and How We Got Here is a captivating glimpse into humankind--where we came from and what that says about our lives today.

In this thought-provoking book, Denis Noble formulates the theory of biological relativity, emphasising that living organisms operate at multiple levels of complexity and must therefore be analysed from a multi-scale, relativistic perspective. Noble explains that all biological processes operate by means of molecular, cellular and organismal networks. The interactive nature of these fundamental processes is at the core of biological relativity and, as such, challenges simplified molecular reductionism. Noble shows that such an integrative view emerges as the necessary consequence of the rigorous application of mathematics to biology. Drawing on his pioneering work in the mathematical physics of biology, he shows that what emerges is a deeply humane picture of the role of the organism in constraining its chemistry, including its genes, to serve the organism as a whole, especially in the interaction with its social environment. This humanistic, holistic approach challenges the common gene-centred view held by many in modern biology and culture.