Discover the 6,000 year old secret to finally getting well, losing weight and feeling alive again Every year we spend more and more on healthcare, research and pharmaceuticals, yet every year the rate of auto-immune, Alzheimer's, digestive disorders, diabetes and diseases of all types continue to rise. Soon 1 out of 2 people will get cancer in their life time and 2 out 3 people will be overweight. Clearly what we're doing is not working and there must be something that's being overlooked... It turns out the answer is simpler than we think and it lies in the oldest form of medicine in the world. The Rain Barrel Effect explains exactly how we get sick, put on weight, and begin to breakdown over time, as well as how to reverse that process and take back control of your life

You can use this book to design a house for yourself with your family; you can use it to work with your neighbors to improve your town and neighborhood; you can use it to design an office, or a workshop, or a public building. And you can use it to guide you in the actual process of construction.

After a ten-year silence, Christopher Alexander and his colleagues at the Center for Environmental Structure are now publishing a major statement in the form of three books which will, in their words, lay the basis for an entirely new approach to architecture, building and planning, which will we hope replace existing ideas and practices entirely. The three books are The Timeless Way of Building, The Oregon Experiment, and this book, A Pattern Language.

At the core of these books is the idea that people should design for themselves their own houses, streets, and communities. This idea may be radical (it implies a radical transformation of the architectural profession) but it comes simply from the observation that most of the wonderful places of the world were not made by architects but by the people.

At the core of the books, too, is the point that in designing their environments people always rely on certain languages, which, like the languages we speak, allow them to articulate and communicate an infinite variety of designs within a forma system which gives them coherence. This book provides a language of this kind. It will enable a person to make a design for almost any kind of building, or any part of the built environment.

Patterns, the units of this language, are answers to design problems (How high should a window sill be? How many stories should a building have? How much space in a neighborhood should be devoted to grass and trees?). More than 250 of the patterns in this pattern language are given: each consists of a problem statement, a discussion of the problem with an illustration, and a solution. As the authors say in their introduction, many of the patterns are archetypal, so deeply rooted in the nature of things that it seemly likely that they will be a part of human nature, and human action, as much in five hundred years as they are today

Develop a strong foundation in the concepts and principles of toxicology with this concise and accessible resource

A Doody's Core Title for 2024 & 2023!

For more than 25 years, Casarett & Doull's Toxicology: The Basics of Poison has set the standard for providing thorough, academic, and authoritative information in clear and engaging ways. Distilling the major principles and concepts from that renowned text, Casarett & Doull's Essentials of Toxicology delivers an accessible and highly readable introduction to the science and clinical field of medical toxicology. The book reflects the expertise of more than 60 renowned contributors.

Presented in full-color, this new edition builds on the wide success of previous editions, with extensive updates that make the book more clinically relevant to students and beginners in toxicology, pharmacology, pharmacy, and environmental sciences. Chapter-ending self-assessment Q&As and other features make the learning process more effective and efficient.

Casarett and Doull's Essentials of Toxicology is organized into seven units:

• General Principles of Toxicology
• Disposition of Toxicants
• Non-organ-directed Toxicity
• Target Organ Toxicity
• Toxic Agents
• Environmental Toxicology
• Applications of Toxicology

Succinct, yet comprehensive, the text covers essential principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents--from pesticides to radiation.

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Fourth Edition, Volume Five: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals, and biologics. This book continues coverage of Organ-Specific Toxicologic Pathology and major organ systems not covered in Volume Four, and has been completely revised, making it an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.

Doubt is our product, a cigarette executive once observed, since it is the best means of competing with the 'body of fact' that exists in the minds of the general public. It is also the means of establishing a controversy.
In this eye-opening expose, David Michaels reveals how the tobacco industry's duplicitous tactics spawned a multimillion dollar industry that is dismantling public health safeguards. Product defense consultants, he argues, have increasingly skewed the scientific literature, manufactured and magnified scientific uncertainty, and influenced policy decisions to the advantage of polluters and the manufacturers of dangerous products. To keep the public confused about the hazards posed by global warming, second-hand smoke, asbestos, lead, plastics, and many other toxic materials, industry executives have hired unscrupulous scientists and lobbyists to dispute scientific evidence about health risks. In doing so, they have not only delayed action on specific hazards, but they have constructed barriers to make it harder for lawmakers, government agencies, and courts to respond to future threats. The Orwellian strategy of dismissing research conducted by the scientific community as junk science and elevating science conducted by product defense specialists to sound science status also creates confusion about the very nature of scientific inquiry and undermines the public's confidence in science's ability to address public health and environmental concerns Such reckless practices have long existed, but Michaels argues that the Bush administration deepened the dysfunction by virtually handing over regulatory agencies to the very corporate powers whose products and behavior they are charged with overseeing.

In Doubt Is Their Product Michaels proves, beyond a doubt, that our regulatory system has been broken. He offers concrete, workable suggestions for how it can be restored by taking the politics out of science and that concern for public safety, rather than private profits, guides our regulatory policy.

Acepta un futuro libre de hongos!

Gracias por visitar CLOTRIMAZOL: Una guía completa sobre las infecciones por hongos, su tratamiento y el bienestar de la piel. Su boleto para superar las infecciones por hongos y alcanzar la cima de la salud y el bienestar de la piel es este manual instructivo.

We live in a toxic world. Environmental pollution and disease-causing germs assault us continually day after day. Our food is nutrient deficient and our water supply dangerously contaminated. People today are exposed to chemicals in far greater concentrations than were previous generations. Diseases that were rare or unheard of a century ago are now raging upon us like a plague. Millions are dying from diseases that were virtually unknown in the past. Experts tell us that by the time we reach middle age, each one of us will have already been affected by either cancer, cardiovascular disease, or some other serious degenerative condition. Conventional medicine has no sure cure. Drugs, surgery, and radiation treatments can be as dangerous and debilitating as the diseases they attempt to cure. This book outlines the steps you need to take to thoroughly detoxify and cleanse your body from these disease-causing agents. You will also learn how to reduce your toxic exposure and how to strengthen your immune system.

Toxicology is the field of science that is focused on the study of the symptoms, making a diagnosis and developing a treatment strategy for the individuals exposed to toxins and venoms. Some of the factors that contribute to the exposure and its consequences are route of exposure, the dosage, age, sex and environment. Medical toxicologists in intensive care units, emergency departments and other inpatient units, provide direct treatment and consultation to acutely poisoned children and adults. Providing advanced evidence-based patient care is also under the scope of clinical toxicology. Evaluating the health impact from chronic and acute exposure to toxic substances in the workplace or outside is also under the scope of this field. This book unravels the recent studies in the field of clinical toxicology. Also included herein is a detailed explanation of the various principles and mechanisms of clinical toxicology. The extensive content of this book provides the readers with a thorough understanding of the subject.

MONITORING FOR HEALTH HAZARDS AT WORK

Monitoring for Health Hazards at Work remains the seminal textbook on measuring and -controlling the risk of workplace exposure to physical, chemical, and biological hazards. Designed for students studying occupational hygiene and exposure science, this comprehensive and accessible volume provides step-by-step guidance on identifying hazards and quantifying their risks in various workplace environments. Complete with checklists and practical examples, the authors present clear explanations of all types of hazards that can arise in the workplace, including dust, particles, fibrous aerosols, gases, vapours, and bioaerosols.

The fifth edition features revised material throughout, and remains an essential resource for students and professionals in occupational hygiene, reflecting global standards and recent developments in monitoring equipment, modelling methods, exposure assessment, and legislation on workplace safety.

Several new or substantially revised chapters cover topics such as human biomonitoring, exposure modelling, hazardous substances, physical agents, evaluating ventilation, PPE, and other control measures

Updated sections discuss the equipment currently available, the importance of risk communication, assessing dermal and inadvertent ingestion exposures, and more

Examines common workplace comfort issues such as noise, vibration, heat and cold, and lighting

Offers practical advice on conducting and presenting risk assessments and reports

Discusses the future of the development and application of hazard measurement equipment and methods

Monitoring for Health Hazards at Work, is required reading for students and professionals in occupational hygiene, environmental health and safety, occupational health and safety, and exposure science.

Make your child's days fun with this dot to dot. Even better than a screen when you're bored.

Dot-to-dot is a very fun and educational exercise. This one consists of a set of dots to connect in order to obtain a picture.
These activities are excellent for improving hand-eye coordination as visual motor control is developed through dot-to-dot work, motor skills, concentration and especially creativity.

Features:

• 50 entertaining and educational dot-to-dot puzzles. (only animals)
• Can be colored once the dots are connected.

Excellent gift for children

In the early 1950s, numerous cases of organic mercury poisoning were discovered in the fishing villages around Minamata, Japan. Yet for decades after, victims of what is now known as Minamata disease suffered neglect, discrimination, and ostracism by Minamata residents, local government, labor unions, Minamata disease certification committees, and fishers' cooperatives. Fifty years later, renewed efforts began to conserve the environment and reconcile with victims of poisoning, including a flurry of museum-building, citizen waste recycling campaigns, and conferences, symposia, and exhibitions. But this rapprochement in the 1990s took place slowly and with difficulty, as the pain of previous decades was still alive and aching. Ishimure Michiko served as a key activist and spokesperson for the Minamata protest movement, producing over forty volumes of writings in various genres: docufiction, historical novels, reportage, autobiography, poetry, children's books, and a Nō drama. Beyond playing an outsized role in organizing the Minamata struggle, Ishimure influenced the movement's cultural history and memory and articulated its symbolic legacy. Paradise in the Sea of Sorrow is a powerful record of victims' suffering and the movement to support them. Its lyrical descriptions of fishing villages and fishers' way of life, as well as of the scenic beauty of the Shiranui Sea area, are among the most effective in contemporary Japanese literature. Paradise is a work of testimonial resistance literature--a militant, hybrid autoethnography featuring both a local community as a plurality of speakers and an autobiographical voice through which Ishimure plays an unassuming participant observer who insists on the accuracy, truthfulness, and necessity of her testimony.

****NOTE: The newer FIFTH EDITION, released 8 April 2022 with more up-to-date materials, is currently in stock at https: //www.amazon.com/dp/B09X3Z5WN3****. The core content difference between this Fourth and the Third Edition is minimal. In addition to the correction of the typos found in the Third Edition, this Fourth Edition has made minor refinements but updated substantially the status and the discussion of numerous contemporary issues covered in this book. In particular, this Fourth Edition has highlighted a number of recent public health and regulatory concerns, including the global concerns with the recent pandemics of Zika as well as Ebola and the U.S. Food and Drug Administration's ban on trans fats in all American processed foods by 2018. Moreover, it has updated the five persistent organic pollutants that the Stockholm Convention has added to its action list since the publication of this book's Third Edition in 2014. As three more update examples, this book is now current with the latest estimate data available concerning the annual amounts of pesticide active ingredients used in the United States and worldwide. It is now consistent with the International Agency for Research on Cancer's latest determinations made on the human carcinogenicity potential of the biological, physical, and chemical agents that the agency has analyzed. Furthermore, it is now up to date with the chemical elements included in the current periodic table.As with the earlier editions, this Fourth Edition offers an introductory text on the scope and principles for as well as the relevant topics of environmental toxicology. To this end, the book is organized into 23 chapters under four parts (sections) as listed below.
PART I. TOXICOLOGIC CONCEPTS AND ENVIRONMENTAL ISSUES: (1) Scope and Principles for/of Environmental Toxicology; (2) Environmental Changes and Environmental Health; (3) Environmental Pollution and Regulatory Agencies; (4) Occurrence and Types of Environmental Toxicants; and (5) Fate and Transport of Toxicants in the Environment.
PART II. BIOACCUMULATION AND BIODISPOSITION OF TOXICANTS: (6) Bioaccumulation of Persistent Environmental Toxicants; (7) Uptake, Distribution, and Excretion of Toxicants; (8) Metabolism/Biotransformation of Xenobiotics; (9) Adverse Action/Toxic Response; and(10) Factors and Conditions Affecting Toxicity.
PART III. NATURE AND EFFECTS OF ENVIRONMENTAL TOXICANTS: (11) Air Pollutants - I: Inorganic Gases;(12) Air Pollutants - II: Particulate Matter;(13) Volatile Organic Compounds;(14) Toxic and Radioactive Metals;(15) Pesticides and Pesticide Residues;(16) Persistent Toxic Substances; and(17) Biological and Underrated Physical Toxic Agents.
PART IV. SPECIAL TOPICS, ISSUES, CONSIDERATIONS, AND FOCI: (18) Environmental Mutagenesis/Carcinogenesis;(19) Reproductive Toxicity and Endocrine Disruption;(20) Occupational Toxicology/Workplace Hazards;(21) Food Toxicants and Toxic Household Substances;(22) Human Health Aspects of Ecotoxicology; and(23) Environmental Health Risk Assessment.

Germ cells have a unique and critical role as the conduit for hereditary information. The issue of male germline mutagenesis and the effects on developmental defects in the next generation has become increasingly high profile in recent years. Understanding the mechanisms by which the germline is induced and maintained is one of the effective ways to treat infertility and cancer. Male-mediated Developmental Toxicity discusses these issues and provides analysis of the fundamental mechanisms of mutations covering both clinical and experimental aspects. It helps clarify the data explaining how genotoxicity involves multiple modes of action and highlights novel models and assays being used to assess germ cell genotoxicity.

With a clear focus on the various mechanisms that could impact human health, this book is for postgraduate students and researchers in reproductive and developmental toxicology as well as those with an interest in the fields of genetically inherited diseases, developmental biology and, potentially, those with a more clinical background.

Veterinary Toxicology: Basic and Clinical Principles, Fourth Edition is a unique single reference that provides a comprehensive overview on the basic principles of veterinary toxicology to any student at the DVM, MS, or PhD level while also continuing to serve as a clinical reference for practitioners. The book thoroughly updates toxicologists and advanced students on the newest approaches for diagnosing poisoning cases in all animals from chemicals, plants, and accidental or malicious intents. Many chapters are provided on topics not covered in any previous books, such as target organ toxicity, radiation and radioactive materials, FDA regulatory issues, and ethics in veterinary toxicology.

Completely revised and updated to include the most recent developments in the field animal toxins, toxicokinetics mechanism of action, toxicity, and treatment, this book is an essential resource for researchers, practicing veterinary toxicologists, advanced students in toxicology, poison control centers, as well as environmentalists, marine biologists, and animal scientists.

As with the previous editions, Introduction to Toxicology, Fourth Edition, continues to chart the evolution of the field of toxicology, from the use of natural toxins by ancient tribes through the developments established by Paracelsus, and progresses through to the current topics in the public interest. For centuries, the study of toxicology has fascinated students. The book begins with basic toxicological principles, including an historical summary, dose-response relationships (NEW chapter), exposure-response relationships (NEW chapter), disposition, and metabolism of xenobiotic toxic substances. Other important new chapters include target organ toxicity, toxicity of carcinogenic agents and new and updated concepts in toxicity testing, and antidotes and treatment of poisonings. In all, nine new or expanded chapters from the third edition are advanced.

Current concerns about the effects of therapeutic drugs, carcinogens, industrial toxins, pesticides, and herbicides on human health, animal welfare, and the stability and maintenance of the ecosystem continue to highlight toxicology as an important and growing scientific discipline.

Key features:

• Comprehensive coverage of the field of toxicology which illustrates its importance to and impact on society
• Uses pertinent examples, tables, and diagrams to aid understanding with learning objectives, summaries, questions, and answers for each chapter
• Clearly and concisely written and presented concepts for easy comprehension by toxicology, biomedical, and health science students
• Examines the complex interactions associated with toxicological events
• Covers the effect of toxins on biological and physiological systems

This book successfully condenses the diffuse literature in the field into an accessible and readable text, made easier with the insertion of many tables and figures. It introduces fundamental concepts and builds upon these using topical and relevant historical examples. Its improved format includes learning objectives and summaries of each chapter, as well as questions and answers suitable for self-assessment.

This latest edition is an invaluable resource for undergraduate and graduate toxicology students, as well as an introductory text for other health care students and professionals. The book also functions as a comprehensive introductory reference text for environmental scientists, medical biologists and chemists, chemical engineers, and regulatory agencies, with interests in toxicologically related areas.

Jessica Düber

Self-Determined Dying with Poisonous Plants
-
The Yew

Using poisonous plants to induce death is an option that has not had a good reputation in the euthanasia literature of recent years. The actual active ingredient content of the plant is often too uncertain, the effects too incalculable, and the death, often experienced while fully conscious, too agonizing. And indeed, the symptoms caused by herbal poisoning that precede death do not sound pleasant in any case. Thus, in my work so far, I have also focused on the currently modern methods - besides inducing hypoxia through various approaches, these are mainly methods in which drugs are taken in severe overdose.

However, the perfect dying pill does not exist or is not available for people willing to die - due to lack of political will (e.g., pentobarbital, which in high doses leads to a peaceful sleep followed by a peaceful death and which is also used for rapid and painless euthanasia of non-human animals). Thus, in methods that induce death by drug overdose, one usually uses a combination of different agents. Again, it is often the case that the lethal agent alone would result in a very unpleasant death and therefore must be combined with a strong sleeping agent so that the dying process is not consciously experienced. To be able to use poisonous plants for self-determined dying, they should also be combined with additional substances (antiemetics, and strong sleeping pills). With this premise in mind, I looked at poisonous plants and examined their potential uses for suicide.The great advantage of herbal poisons is that they are very easy to obtain and we cannot be denied access to them. In the use of pharmaceuticals, we depend on availability in pharmacies, on the black market, or just liberal legislation. With sufficient knowledge about the possibilities of nature, on the other hand, no one will be able to restrict us in our self-determination. Therefore, I would like to introduce the yew tree in this little booklet.

Safeguarding economic prosperity, whilst protecting human health and the environment, is at the forefront of scientific and public interest. This book provides a practical and balanced view on toxicology, control, risk assessment and risk management, addressing the interplay between science and public health policy. This revised edition provides a detailed analysis on chemical and by-product exposure, how they enter the body and the suitability of imposed safety limits. Chapters on dose, with particular emphasis on children and vulnerable subpopulations, reproductive and developmental toxicants and toxicity testing are included. With updated and comprehensive coverage of international developments of risk management and safety, this will have broad appeal to researchers and professionals involved in chemical safety and regulation as well as the general reader interested in environmental pollution and public health.

Lead, mercury, arsenic, and cadmium are major toxic metals. All are environmental pollutants that can inflict harm on humans and other living creatures as well as adversely affect our air, water, soil, and food supply. They can poison not only us but also our progeny developing in the womb. They can break down the body's basic functions. This book describes the unique characteristics of each of the four major toxic metals, identifies the likely sources of our exposure, and offers in-depth, evidence based information, methods to test for its presence, and therapies to rid ti from our bodies.