The Voice of Clinical Reason

A Doody's Core Title for 2024 & 2023!
Harrison's Principles of Internal Medicine is the world's most trusted clinical medicine text--and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison's Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine.

Written and edited by the world's top experts in their respective fields, this landmark guide provides comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease.

Harrison's is world-renowned as the most authoritative source for:

- Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases
- The physiologic and etiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow
- Updated clinical trial results and recommended guidelines
- Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings
- Coverage of both therapeutic approaches and specific treatment regimens
- Practical clinical decision trees and algorithms
- Organ/system-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, and general and specific approaches to therapy

Harrison's remains the most trusted resource in a world influenced by endless sources of medical information. The most timely and comprehensive updates from the world's top experts are featured in the 21st edition:

- Current coverage of the diagnosis and treatment of diseases, from COVID to dementia to sepsis to multiple sclerosis to lung cancer
- Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries
- More than 1000 clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes
- Numerous atlases featuring curated collections of important visual aspects of diagnosis and management
- Updated and time-saving curation and synthesis of established and new medical literature and studies
- Clinically relevant coverage of disease mechanics and pathophysiology, and related therapeutic mechanisms

Why do we love music? What enables us to create it, perceive it, and enjoy it? In From Perception to Pleasure, Robert Zatorre provides answers to these questions from the perspective of cognitive neuroscience, explaining how we get from perception of sound patterns to pleasurable responses. The book is organized around a central thesis: that pleasure in music arises from interactions between cortical loops that enable processing of sound patterns, and subcortical circuits responsible for reward and valuation. This model integrates knowledge derived from basic neuroscience of the auditory system and of reward mechanisms with the concept that perception and pleasure depend on mechanisms of prediction, anticipation, and valuation.

The first part of the book describes the pathways to and from the auditory cortex that generate internal representations of musical structure at different levels of abstraction, which then interact with memory, sensory-motor, and other cognitive mechanisms that are essential to perceive and produce music. The second part of the book focuses on the functional anatomy of the dopaminergic reward system; its involvement in musical pleasure; the links between prediction, surprise, and complexity; and what happens when the system is disrupted.

The book is richly illustrated to help the reader follow the scientific findings. Most of all, From Perception to Pleasure provides an integrative model for a large body of scientific knowledge that explains how patterns of abstract sounds can generate profoundly moving hedonic experiences.

Diabetics often have problems with their feet that can lead to infection and amputation. In this book, Dr. Aaranson provides a complete guide that addresses how to take care of your feet if you are a diabetic. Diabetics often experience neuropathy in their feet--they can't feel anything, so they aren't aware when problems are developing. In such cases, if not caught early or even prevented through daily foot care, the person can lose the toes or foot to amputation. This doesn't have to happen, and Dr. Aaranson shows you how to prevent such a catastrophe.

From one of the world's top virologists, the definitive guide to understanding--and navigating--COVID-19.

Three years on, COVID is clearly here to stay. So what do we do now? Drawing on his expertise as one of the world's top virologists, Dr. Paul Offit helps weary readers address that crucial question in this brief, definitive guide.

As a member of the FDA Vaccine Advisory Committee and a former member of the Advisory Committee for Immunization Practices to the CDC, Offit has been in the room for the creation of policies that have affected hundreds of millions of people. In these pages, he marshals the power of hindsight to offer a fascinating frontline look at where we were, where we are, and where we're heading in the now-permanent fight against the disease.

Accompanied by a companion website populated with breaking news and relevant commentary, this book contains everything you need to know to navigate COVID going forward. Offit addresses fundamental issues like boosters, immunity induced by natural infection, and what it means to be fully vaccinated. He explores the dueling origin stories of the disease, tracing today's strident anti-vax rhetoric to twelve online sources and tracking the fallout. He breaks down long COVID--what it is, and what the known treatments are. And he looks to the future, revealing whether we can make a better vaccine, whether it should be mandated, and providing a crucial list of fourteen takeaways to eradicate further spread.

Filled with pragmatic analysis and sensible advice, TELL ME WHEN IT'S OVER is for anyone interested in finding new solutions to the new normal.

Joining the ranks of modern myth busters, Dr. Sharon Moalem turns our current understanding of illness on its head and challenges us to fundamentally change the way we think about our bodies, our health, and our relationship to just about every other living thing on earth, from plants and animals to insects and bacteria.

So why does disease exist? Moalem proposes that most common ailments--diabetes, hemochromatosis, cystic fibrosis, sickle cell anemia--came into existence for very good reasons. At some point they helped our ancestors survive some grand challenge to their existence. Examining the evolution of man, Moalem reveals the role genetic and cultural differences have played in the health and well-being of various races, including their susceptibility to disease.

With mesmerizing insight, Moalem offers groundbreaking insight into:

- How diabetes may be a biproduct of a mechanism that helped humans survive the Ice Age

- Why African Americans living in the north might suffer from vitamin D deficiencies,

- Why Asians can't drink as much alcohol as Europeans

Revelatory, utterly engaging, and timely--Moalem ponders strongN1, the emerging Avian Flu virus--Why Redheads Feel More Pain and Asians Can't Drink will irrevocably change the way we think about our bodies and ourselves.

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics.

Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.

Medicine is hard.

Writing about medicine doesn't have to be.

Struggling to write your character's chronic illness? Need to injure a character but don't know how? Look no further! Let physician and author, Natalie Dale, MD, be your guide to writing about medicine.

In Volume 1: Setting & Character, Dr. Dale navigated writers through the complex maze of hospital settings and medical professions. Now, the doctor is back, tackling one of fiction writers' biggest and most important questions: how to believably injure, poison, sicken, maim, mutilate, disable, or otherwise cause harm to their beloved characters.

In Volume 2: Illness & Injury, you'll learn:

- How to believably injure characters-and the treatment they'll need to survive.

- Which life-threatening conditions might afflict your young, otherwise healthy character.

- How to describe tough medical situations, such as suicide, miscarriage, and cancer.

- How to avoid medical clichés and harmful misrepresentations.

- And much, much more!

Volume 2: Illness & Injury is packed with straightforward, practical, and sometimes hilarious advice that will transform your writing about medicine from a research nightmare to an enjoyable adventure.

Clear, concise, and filled with accessible and usable current medical facts that will add depth and credibility to any story, the A WRITER'S GUIDE TO MEDICINE series is a must-have for every writer's reference shelf.

- DP Lyle, MD, award-winning author of the Jake Longly and Cain/Harper thriller series.

An absolute must for any writer of fiction wanting to get their medical facts correct. Dr. Dale writes a compelling and informative book that should be required reading for anyone delving into the world of hospitals, medicine and trauma

- Neil Bradbury, PhD, author of A Taste for Poison: Eleven Deadly Molecules and the Killers Who Used Them

For thousands of years, Western culture has dichotomized science and art, empiricism and subjective experience, and biology and psychology. In contrast with the prevailing view in philosophy, neuroscience, and literary criticism, George Engel, an internist and practicing physician, published a paper in the journal Science in 1977 entitled The Need for a New Medical Model: A Challenge for Biomedicine. In the context of clinical medicine, Engel madethe deceptively simple observation that actions at the biological, psychological, and social level are dynamically interrelated and that these relationships affect both the process and outcomes of care.
The biopsychosocial perspective involves an appreciation that disease and illness do not manifest themselves only in terms of pathophysiology, but also may simultaneously affect many different levels of functioning, from cellular to organ system to person to family to society. This model provides a broader understanding of disease processes as encompassing multiple levels of functioning including the effect of the physician-patient relationship.
This book, which containsEngel's seminal article, looks at the continuing relevance of his work and the biopsychosocial model as it is applied to clinical practice, research, and education and administration.

Contributors include: Thomas Inui, Richard Frankel, Timothy Quill, Susan McDaniel, Ronald Epstein, Peter Leroux, Diane Morse, Anthony Suchman, Geoffrey Williams, Frank Degruy, Robert Ader, Thomas CampbelL, Edward DecI, Moira Stewart, Elaine Dannefer, Edward Hundert, Lindsey Henson, Robert Smith, Kurt Fritzsche, Manfred Cierpka, Michael Wirsching, Howard Beckman, and Theodore Brown.

In 2008 Dr. Afrin started coming to understand that a newly recognized type of mast cell disease, now called mast cell activation syndrome (MCAS), was the underlying diagnosis in many patients he was seeing who were each suffering large assortments - quite different from one patient to the next - of chronic multisystem inflammatory illnesses of unclear cause. Dr. Afrin soon gained experience that MCAS is far more prevalent than the only mast cell disease previously known to medicine (the rare disease of mastocytosis) and that most MCAS patients, once accurately diagnosed, can eventually find significantly helpful medications targeted at the disease. The frequency and magnitude of the improvements Dr. Afrin has seen - even the relief that comes from finally having a unifying diagnosis other than psychosomatism - have spurred him to focus in this area, not only tending to the needs of his patients but also pursuing research to advance our understanding of the disease and helping to educate other professionals who in turn can help even more of the many people who have long been suffering not only the symptoms of the disease but also the natural concern of not understanding why one would be so unlucky to have acquired so many medical problems. As it turns out, such patients are not so unlucky and truly have just one root issue (and a very common one at that), which has the biological capability to develop, directly or indirectly, into most or all of their previously diagnosed problems. There is a great deal yet to learn about this, but even with just the present very limited understanding, the opportunity to diagnose and help patients with MCAS seems to be enormous and Dr. Afrin felt a description of the disease, written for the general public, might help lead some MCAS patients on a journey to diagnosis and improvement sooner rather than later. Dr. Afrin hopes this book will help people who might have, or do have, MCAS. A portion of the proceeds of purchases of this book will go to support research and education in this area.

Dr. Afrin earned a B.S. in computer science at Clemson University in 1984 and then an M.D. at the Medical University of South Carolina (MUSC) in 1988, where he also pursued internal medicine residency and hematology/oncology clinical and research fellowships. While on faculty at MUSC from 1995-2014, he was active in undergraduate and graduate medical education, educational and information technology administration, and practice and research in hematology/oncology and medical informatics. Since the mid-'00s, his clinical work has increasingly focused in hematology, especially mast cell disease. In 2008 Dr. Afrin started coming to understand that a newly recognized type of mast cell disease, now called mast cell activation syndrome (MCAS), was the underlying diagnosis in many patients he was seeing who were each suffering large assortments -- quite different from one patient to the next -- of chronic multisystem inflammatory illnesses of unclear cause. Dr. Afrin soon gained experience that MCAS is far more prevalent than the only mast cell disease previously known to medicine (the rare disease of mastocytosis) and that most MCAS patients, once accurately diagnosed, can eventually find significantly helpful medications targeted at the disease. The frequency and magnitude of the improvements Dr. Afrin has seen -- even the relief that comes from finally having a unifying diagnosis other than psychosomatism -- have spurred him to focus in this area, not only tending to the needs of his patients but also pursuing research to advance our understanding of the disease and helping to educate other professionals who in turn can help even more of the many people who have long been suffering not only the symptoms of the disease but also the natural concern of not understanding why one would be so unlucky to have acquired so many medical problems. As it turns out, such patients are not so unlucky and truly have just one root issue (and a very common one at that) which has the biological capability to develop, directly or indirectly, into most or all their previously diagnosed problems. There is a great deal yet to learn about this, but even with just the present very limited understanding, the opportunity to diagnose and help patients with MCAS seems to be enormous and Dr. Afrin felt a description of the disease, written for the general public, might help lead some MCAS patients on a journey to diagnosis and improvement sooner rather than later. He joined the University of Minnesota in 2014 to further his interests in this area. He has an extensive record of peer-reviewed publications and has spoken widely in his areas of interest.

If you have questions pertaining to Dr. Afrin's book, or would like more information, please email info@mastcellresearch.com.

You can also visit www.mastcellresearch.com. Or, find us on Facebook @facebook.com/mastcellresearch/, and Twitter @MastCellHelp.

So many suffer from it, yet so few know of it: Chronic Inflammatory Response Syndrome. Through story and investigation, one of its many sufferers shines a light on this mysterious illness.

From the earliest signs of the environmentally acquired illness called Chronic Inflammatory Response Syndrome (CIRS) to the implications of a future with CIRS, Viviane Lovato takes you along her journey with this complex condition that causes chronic fatigue, fibromyalgia, and more. She goes in-depth into its effects on her health, her life - both personal and professional - her family, and those around her. It's a story full of ups and downs, heart-wrenching truths, and hope.

After revealing on a deep and personal level what it means to live with CIRS, Viviane covers in detail the many hurdles facing those with this complex disease. From finding a doctor who can diagnose you to seeking out the professionals needed for effective treatment, she covers why these barriers exist, what is being done to overcome them, and what else can and needs to be done so that more than just the lucky few can recover.

From the foreword by world-leading Lyme expert Joseph J. Burrascano, Jr., MD:

A detailed and thoughtful road map is sorely needed. And it is in this context that I am so pleased that we have this book by Dr. Kinderlehrer. I wish I'd had a book like this back in the day to guide me! It covers just about everything--the infections, diagnostic tests, treatments, and yes, the all-important terrain. It gives the reader an in-depth, but easily understandable, guide through the many subtleties of tick-borne illnesses. I am impressed with the knowledge presented and grateful for this information, which has helped so many people recover from chronic illness.

To anyone touched by tick-borne diseases, be they a patient, a caregiver, loved one, or health practitioner, this book is a must-read. It will serve as a continuing reference as it gets read and reread to assimilate all it has to offer. I congratulate Dr. Kinderlehrer and thank him for this most impressive work.

By far the most thorough work available on Lyme Disease Complex, this book provides patients with information that will guide them on their healing journeys, as well as supplying doctors with instruction on appropriate diagnosis and treatment approaches.

Lyme Disease is a major problem. While the CDC reported 427,000 new cases in 2017 based on surveillance criteria, actual numbers based on clinical diagnosis put that number at well over one million. It is now well accepted that 10 to 20 percent of these cases go on to become a chronic illness, and these numbers don't even include those people who became chronically ill without ever witnessing a tick attachment or a bull's-eye rash. In other words, hundreds of thousands of people develop a chronic illness every year with Lyme disease.

This is why Dr. Kinderlehrer's book is so critical and timely and has the potential to help millions who are victims of this epidemic. His integrative approach offers the most up-to-date and comprehensive plan available for treating and beating this disease. It discusses brand new treatments such as disulfiram, which is being hailed as a major breakthrough, as well as the use of cannabis to treat pain, anxiety, and inflammation among other developments in the field. With the staggering growth we are seeing in numbers of people afflicted, this book becomes more important every day.

This book is about a little boy with Sickle Cell disease. Kids who have sickle cell disease may feel pain in different parts of the body when blood vessels get clogged with sickle cells. The pain can last a few hours or several days, and it might hurt a lot or just a little. This story tells about the countless hospital visits and how he and his mother deal with it. Follow along as you get a glimpse of the day in the life of Jaden

A book for cancer sufferers and those wishing to prevent it, written by the Medical Director and the Nutritional Advisor to the famous Bristol Cancer Help Centre

Eat To Beat Cancer shows that there are ways you can help yourself to:
- Eat well to avoid the onsett of serious illness
- Keep cancer in remission
- Use nutrition to fight cancer.

Dr Rosy Daniel Explains:
- Why Change The Way You Eat?
- How To Change The Way You Eat - and make the change easy.
- What To Change In The Way You Eat - what's really important.
- Food As Therapy - including detoxification, raising your energy levels, correcting nutritional imbalances.

All recipes are free from animal products,
saturated fat and are low in salt and sugar.

⭐⭐ Second Edition: Edited and Extended ⭐⭐

Did you know you could stimulate your Vagus Nerve easily every day to improve your memories your breath and your heart?
Did you know you could activate your Vagus Nerve to decrease your anxiety and cure chronic illness, PTSD, anxiety and depression?

In the present quick moving world, you get barraged with day by day nervousness that doesn't leave your head in any event, during ends of the week. The working way of life expects you to leave brief period left to deal with yourself.

The uplifting news is, you can begin dealing with yourself by just switch on THE VAGUS NERVE, the very nerve that controls the parasympathetic framework. The nerve which, on the off chance that you rub it right, will assuage your pressure and switch off the battle or flight mode for you.

Being the longest nerve among the cranial nerves, the Vagus Nerve meanders from the sides of your neck, over your chest, going through the significant organs like your heart, lungs, liver, etc, to the stomach area. In the event that your cerebrum is the mothership, the vagus nerve is the fundamental system that gives the messages advising organs how to respond.

In this book Daily Vagus Nerve Exercises: Self-Help Exercises to Stimulate Vagal Tone. Relieve Anxiety, Prevent Inflammation, Reduce Chronic Illness, Anxiety, Depression, Trauma, PSDT and Lots More, you will find

• Vagus and its Function

• Vagus Nerve Anatomy Disclosure

• Sensory Infections of Vagus Nerve

• The Benefits of Vagus Nerve

• The Diseases Associated With Vagus Nerve

• Activating Your Vagus Nerve With Daily Exercise

• Substances That May Interfere With The Vagus Nerve

• Vagus Exercises

• Vagus Nerve Stimulation Routine You Can Add to Your Daily Habit

And many content yet highlighted.

Long periods of studies have indicated the association of the mind and the invulnerable framework through the Vagus Nerve, how invigorating the Vagus Nerve causing the synapse discharge into the amygdala and improve the memory, and that's only the tip of the iceberg. This has demonstrated the power covered up in the rear of your neck. It is time you start dealing with this diamond in your body and start mending yourself the correct way.

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