The Voice of Clinical Reason

A Doody's Core Title for 2024 & 2023!
Harrison's Principles of Internal Medicine is the world's most trusted clinical medicine text--and a superb resource for learning the art and science of clinical reasoning. Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison's Principles of Internal Medicine provides the informational foundation you need for the best patient care possible. This new edition is fully updated with timely new chapters and essential updates across the spectrum of internal medicine.

Written and edited by the world's top experts in their respective fields, this landmark guide provides comprehensive, accurate, and essential coverage of the pathogenesis, diagnosis, and treatment of disease.

Harrison's is world-renowned as the most authoritative source for:

- Clear, concise schemas that facilitate the generation of differential diagnoses to reason efficiently through complex real world clinical cases
- The physiologic and etiologic basis of signs and symptoms, which are covered through a wealth of unsurpassed expert guidance and linked to the disease-specific chapters that follow
- Updated clinical trial results and recommended guidelines
- Excellent and extensive visual support, including radiographs, clinical photos, schematics, and high-quality drawings
- Coverage of both therapeutic approaches and specific treatment regimens
- Practical clinical decision trees and algorithms
- Organ/system-specific sections, with clinically relevant pathophysiology and practical clinical advice on the approach to the patient, strategies towards building a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, and general and specific approaches to therapy

Harrison's remains the most trusted resource in a world influenced by endless sources of medical information. The most timely and comprehensive updates from the world's top experts are featured in the 21st edition:

- Current coverage of the diagnosis and treatment of diseases, from COVID to dementia to sepsis to multiple sclerosis to lung cancer
- Updated content that reflects new approved therapeutics and new practice-changing guidelines and evidence summaries
- More than 1000 clinical, pathological, and radiographic photographs, diagnostic and therapeutic decision trees, and clear schematics and diagrams describing pathophysiologic processes
- Numerous atlases featuring curated collections of important visual aspects of diagnosis and management
- Updated and time-saving curation and synthesis of established and new medical literature and studies
- Clinically relevant coverage of disease mechanics and pathophysiology, and related therapeutic mechanisms

Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in network medicine, this definitive volume provides readers with a state-of-the-art synthesis of the progress being made and the challenges that remain.

Medical researchers have long sought to identify single molecular defects that cause diseases, with the goal of developing silver-bullet therapies to treat them. But this paradigm overlooks the inherent complexity of human diseases and has often led to treatments that are inadequate or fraught with adverse side effects. Rather than trying to force disease pathogenesis into a reductionist model, network medicine embraces the complexity of multiple influences on disease and relies on many different types of networks: from the cellular-molecular level of protein-protein interactions to correlational studies of gene expression in biological samples. The authors offer a systematic approach to understanding complex diseases while explaining network medicine's unique features, including the application of modern genomics technologies, biostatistics and bioinformatics, and dynamic systems analysis of complex molecular networks in an integrative context.

By developing techniques and technologies that comprehensively assess genetic variation, cellular metabolism, and protein function, network medicine is opening up new vistas for uncovering causes and identifying cures of disease.

Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.

When Maria Velasquez began to hear the thoughts of others, she knew life would never be the same; but the possibility she could be the savior of not only the world, but an entire galaxy had never crossed her mind. Now Maria finds herself on a journey of self-discovery that takes her from the suburbs of Manhattan to a planet buried deep in the subgalaxy.Maria's guide on her journey is Wynn, the descendant of Paladins sent here to protect Earth from the impending danger posed by the evil Czar Caiphas, leader of the Galactic Socialist Regime. Their mission is to watch and wait for an earthling to emerge whom they believe could be the Heir to Master Suuth, an ancient Master of the Paladins secreted to our world to protect him from the Czar.Accessible through a rift in space, a phenomenon of light and gravity known as the Cold Star, the subgalaxy is a realm ruled by the opposing forces of magic and faith. Ripe with political intrigue and a never-ending state of galactic war, the clashing of our two galaxies promises an explosive result.Can Wynn and Maria unlock the secrets of the Master's Heir and defeat Czar Caiphas and his Knights? Cold Star is a fast-paced futuristic Galactic Fantasy certain to transport you through time and space and leave you wanting more.

Tommy Shotwell. Ex-Cop. Former FBI and CIA agent. Private Investigator. Compulsive Gambler. Business was not looking good for Tommy Shotwell. Since opening his own private investigator company he had only worked on five cases. Enter Christine Mist. Daughter of multi-millionaire Anthony Mist, with an offer to buy half the agency if Tommy Shotwell would act as a mentor. It had long been her dream to be a private investigator, but Christine had an ulterior motive. Christine's mother had been killed in a lab accident a year earlier, but Christine believes she was murdered. A mysterious letter sent from her mother before she died must mean something other than the gibberish it seemed to be. And Christine wanted answers . . . and revenge. When she shows the letter to Tommy his mood immediately changes from one of humor to a cold-seriousness he rarely shows. For Tommy, the letter has brought up a past he could not forget, a past that has brought him to this present, a past with a nemesis he thought he had left far behind.The Jackal. With the new influx of cash the sale of half his agency would bring, perhaps he could get one step closer to bringing down the person responsible for destroying his life once and for all.

Two Doctors, two tales. In Paradox, Doctor Otis Milo has gone to Mars to investigate the Argyre Planitia Impact Basin, and a strange yet familiar structure buried in the Martian soil. What he finds is the key to his past and his future. In Organ Farm, Doctor Harbaugh has mastered human cloning, and has set up a farm of perfect organ donors for the elite few who could afford to clone their children before they are born. But when the debate over what does and does not constitute human life comes into question, the story takes a horrific turn.

Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.