The gold standard of neuroscience texts―updated with hundreds of brand-new images and fully revised content in every chapter

A Doody's Core Titles for 2024 & 2023!

For more than 40 years, Principles of Neural Science has helped readers understand the link between the human brain and behavior. As the renowned text has shown, all behavior is an expression of neural activity and the future of both clinical neurology and psychiatry is dependent on the progress of neural science. Fully updated, this sixth edition of the landmark reference reflects the latest research, clinical perspectives, and advances in the field. It offers an unparalleled perspective on the the current state and future of neural science.
This new edition features:

• Unmatched coverage of how the nerves, brain, and mind function
• NEW chapters on:
  - The Computational Bases of Neural Circuits that Mediate Behavior
  - Brain-Machine Interfaces
  - Decision-Making and Consciousness
• NEW section on the neuroscientific principles underlying the disorders of the nervous system
• Expanded coverage of the different forms of human memory
• Highly detailed chapters on stroke, Parkinson's disease, and multiple sclerosis
• 2,200 images, including 300 new color illustrations, diagrams, radiology studies, and PET scans

Principles of Neural Science, Sixth Edition benefits from a cohesive organization, beginning with an insightful overview of the interrelationships between the brain, nervous system, genes, and behavior.

The text is divided into nine sections:

Part I: Overall Perspective provides an overview of the broad themes of neural science, including the basic anatomical organization of the nervous system and the genetic bases of nervous system function and behavior.

Part II: Cell and Molecular Biology of Cells of the Nervous System examines the basic properties of nerve cells, including the generation and conduction of propagated signaling.

Part III: Synaptic Transmission focuses on the electrophysiological and molecular mechanism of synaptic transmission with chapters on neuronal excitability, neurotransmitters, and transmitter release.

Part IV: Perception discusses the various aspects of sensory perception, including how information from the primary organs of sensation is transmitted to and processed by the central nervous system.

Part V: Movement considers the neural mechanisms underlying movement and examines a new treatment that addresses how the basal ganglia regulate the selection of motor actions and instantiate reinforcement learning.

Part VI: The Biology of Emotion, Motivation and Homeostasis examines the neural mechanisms by which subcortical areas mediate homeostatic control mechanisms, emotions, and motivation.

Part VII: Development and the Emergence of Behavior looks at the nervous system from early embryonic differentiation to the formation and elimination of synapses.

Part VIII: Learning, Memory, Language and Cognition expands on the previous section, examining the cellular mechanisms of implicit and explicit memory storage, as well as decision-making and consciousness.

Part IX: explores the neural mechanisms underlying diseases and disorders of the nervous system, including autism spectrum disorder, epilepsy, schizophrenia, and anxiety.

When we view a work of art, we often experience an emotional response, but the causes of our reactions are complex. Our knowledge of why we respond to art as we do is rooted in science--in psychology and biology. Eric R. Kandel traces the origins of this understanding to early twentieth-century Vienna, which gave rise to the concept of the beholder's share, the realization that art is incomplete without the perceptual and emotional involvement of the viewer--that is, without our responses to it.

But what causes our response? Our brain is a creativity machine that brings to bear on any image--including a painting--certain innate, universal processes related to sensory perception as well as higher-order processes related to our personal experiences, memories, and emotions. Understanding how these unconscious processes in the brain interact to create the beholder's share is one of the great challenges currently confronting brain science.

The essays on art and science in this book vary widely in subject matter, including the angst-ridden portraits of Soutine, conflicting views of women's sexuality, Cubism's challenge to our innate visual processes, and why we react differently to abstract versus figurative art. But each essay focuses on the interaction of art and science. Woven throughout are the many notable scientists, art historians, artists, and others, both Jewish and non-Jewish, who contributed to our understanding of how we experience art.

Memory binds our mental life together. We are who we are in large part because of what we learn and remember. But how does the brain create memories? Nobel Prize winner Eric R. Kandel intertwines the intellectual history of the powerful new science of the mind--a combination of cognitive psychology, neuroscience, and molecular biology--with his own personal quest to understand memory. A deft mixture of memoir and history, modern biology and behavior, In Search of Memory brings readers from Kandel's childhood in Nazi-occupied Vienna to the forefront of one of the great scientific endeavors of the twentieth century: the search for the biological basis of memory.

A Nobel Prize-winning neuroscientist's probing investigation of what brain disorders can tell us about human nature

Eric R. Kandel, the winner of the Nobel Prize in Physiology or Medicine for his foundational research into memory storage in the brain, is one of the pioneers of modern brain science. His work continues to shape our understanding of how learning and memory work and to break down age-old barriers between the sciences and the arts.

In his seminal new book, The Disordered Mind, Kandel draws on a lifetime of pathbreaking research and the work of many other leading neuroscientists to take us on an unusual tour of the brain. He confronts one of the most difficult questions we face: How does our mind, our individual sense of self, emerge from the physical matter of the brain? The brain's 86 billion neurons communicate with one another through very precise connections. But sometimes those connections are disrupted. The brain processes that give rise to our mind can become disordered, resulting in diseases such as autism, depression, schizophrenia, Parkinson's, addiction, and post-traumatic stress disorder. While these disruptions bring great suffering, they can also reveal the mysteries of how the brain produces our most fundamental experiences and capabilities--the very nature of what it means to be human. Studies of autism illuminate the neurological foundations of our social instincts; research into depression offers important insights on emotions and the integrity of the self; and paradigm-shifting work on addiction has led to a new understanding of the relationship between pleasure and willpower.

By studying disruptions to typical brain functioning and exploring their potential treatments, we will deepen our understanding of thought, feeling, behavior, memory, and creativity. Only then can we grapple with the big question of how billions of neurons generate consciousness itself.

When we view a work of art, we often experience an emotional response, but the causes of our reactions are complex. Our knowledge of why we respond to art as we do is rooted in science--in psychology and biology. Eric R. Kandel traces the origins of this understanding to early twentieth-century Vienna, which gave rise to the concept of the beholder's share, the realization that art is incomplete without the perceptual and emotional involvement of the viewer--that is, without our responses to it.

But what causes our response? Our brain is a creativity machine that brings to bear on any image--including a painting--certain innate, universal processes related to sensory perception as well as higher-order processes related to our personal experiences, memories, and emotions. Understanding how these unconscious processes in the brain interact to create the beholder's share is one of the great challenges currently confronting brain science.

The essays on art and science in this book vary widely in subject matter, including the angst-ridden portraits of Soutine, conflicting views of women's sexuality, Cubism's challenge to our innate visual processes, and why we react differently to abstract versus figurative art. But each essay focuses on the interaction of art and science. Woven throughout are the many notable scientists, art historians, artists, and others, both Jewish and non-Jewish, who contributed to our understanding of how we experience art.

These eight important and fascinating essays by Nobel Prize-winning psychiatrist Eric Kandel provide a breakthrough perspective on how biology has influenced modern psychiatric thought. Complete with commentaries by experts in the field, this book reflects the author's evolving view of how biology has revolutionized psychiatry and psychology.

We learn and remember information by modifying synaptic connections in the neuronal networks of our brain. Depending on the type of information being stored, these changes occur in different regions and different circuits of the brain. The underlying circuit mechanisms are beginning to be understood. These mechanisms are capable of storing or reconstructing memories for periods ranging up to a lifetime, but they are also error-prone, as memories can be distorted or lost.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines important aspects of the neurobiology of learning and memory. Contributors review the various types of memory and the anatomical architectures and specialized cells involved. The induction of synaptic and cell-wide changes during memory encoding, the transcriptional and translational programs required for memory stabilization, the molecular signals that actively maintain memories, and the activation of neural ensembles during memory retrieval are comprehensively covered.

The authors also discuss the model organisms and state-of-the-art technologies used to elucidate these processes. This volume will serve as a valuable reference for all neurobiologists and biomedical scientists as well as for cognitive and computational neuroscientists wishing to explore the remarkable phenomena of learning and memory.

One day in 1996, the neuroscientist Eric R. Kandel took a call from his program officer at the National Institute of Mental Health, who informed him that he had been awarded a key grant. Also, the officer said, he and his colleagues thought Kandel would win the Nobel Prize. I hope not soon, Kandel's wife, Denise, said when she heard this. Sociologists had found that Nobel Prize winners often did not contribute much more to science, she explained.

In this book, Kandel recounts his remarkable career since receiving the Nobel in 2000--or his experience of proving to his wife that he was not yet completely dead intellectually. He takes readers through his lab's scientific advances, including research into how long-term memory is stored in the brain, the nature of age-related memory loss, and the neuroscience of drug addiction and schizophrenia. Kandel relates how the Nobel Prize gave him the opportunity to reach a far larger audience, which in turn allowed him to discover and pursue new directions. He describes his efforts to promote public understanding of science and to put brain science and art into conversation with each other. Kandel also discusses his return to Austria, which he had fled as a child, and observes Austria's coming to terms with the Nazi period. Showcasing Kandel's accomplishments, erudition, and wit, There Is Life After the Nobel Prize is a candid account of the working life of an acclaimed scientist.